Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein

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The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules.

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Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein.

Mutation of the adenomatous polyposis coli (APC) gene is an early step in the development of colorectal carcinomas. APC protein is located in both the cytoplasm and the nucleus. The objective of this study was to define the nuclear localization signals (NLSs) in APC protein. APC contains two potential NLSs comprising amino acids 1767-1772 (NLS1(APC)) and 2048-2053 (NLS2(APC)). Both APC NLSs are...

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Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm.

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 1997

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.94.7.3034